Properties of non‐canonical GC base pairs and their relations with mechanochemical cleavage of DNA are analyzed. A hypothesis of the involvement of the transient GC wobble base pairs both in the mechanisms of the mechanochemical cleavage of DNA and epigenetic mechanisms involving of 5‐methylcytosine, is proposed. The hypothesis explains the increase in the frequency of the breaks of the sugar‐phosphate backbone of DNA after cytosines, the asymmetric character of these breaks, and an increase in break frequency in CpG after cytosine (...) methylation. As an alternative hypothesis, probable implication of GC+ Hoogsteen base pairs is considered, which now exemplify the best‐studied non‐canonical GC base pairs in the DNA double helix. Also see the video abstract here https://youtu.be/EUunVWL0ptw. (shrink)

Automated classification of legal documents has been the subject of extensive research in recent years. However, this is still a challenging task for long documents, since it is difficult for a model to identify the most relevant information for classification. In this paper, we propose a two-stage supervised learning approach for the classification of petitions, a type of legal document that requests a court order. The proposed approach is based on a word-level encoder–decoder Seq2Seq deep neural network, such as a (...) Bidirectional Long Short-Term Memory (BiLSTM) or a Bidirectional Encoder Representations from Transformers (BERT) model, and a document-level Support Vector Machine classifier. To address the challenges posed by the lengthy legal documents, the approach introduces a human-in-the-loop approach, whose task is to localize and tag relevant segments of text in the word-level training part, which dramatically reduces the dimension of the document classifier input vector. We performed experiments to validate our approach using a real-world dataset comprised of 270 intermediate petitions, which were carefully annotated by specialists from the 15th civil unit of the State of Alagoas, Brazil. Our results revealed that both BiLSTM and BERT-Convolutional Neural Networks variants achieved an accuracy of up to 95.49%, and also outperformed baseline classifiers based on the Term Frequency–Inverse Document Frequency test vectorizer. The proposed approach is currently being utilized to automate the aforementioned justice unit, thereby increasing its efficiency in handling repetitive tasks. (shrink)

Using a longitudinal case study design, we have tracked the recovery of motor function following severe traumatic brain injury (TBI) through a multimodal neuroimaging approach. In 2006, Canadian Soldier Captain (retired) Trevor Greene (TG) was attacked with an axe to the head while on tour in Afghanistan. TG continues intensive daily rehabilitation, which recently included the integration of physical therapy (PT) with neuromodulation using translingual neurostimulation (TLNS) to facilitate neuroplasticity. Recent findings with PT+TLNS demonstrated that recovery of motor function occurred (...) beyond conventional time limits, currently extending past 14-years post-injury. To investigate whether PT+TLNS similarly resulted in associated cognitive function improvements, we examined event-related potentials (ERPs) with the brain vital signs framework. In parallel with motor function improvements, brain vital signs detected significant increases in basic attention (as measured by P300 response amplitude) and cognitive processing (as measured by contextual N400 response amplitude). These objective cognitive improvements corresponded with TG’s self-reported improvements, including a noteworthy and consistent reduction in ongoing symptoms of post-traumatic stress disorder (PTSD). The findings provide valuable insight into the potential importance of non-invasive neuromodulation in cognitive rehabilitation, in addition to initial indications for physical rehabilitation. (shrink)

Compiled by an archaeologist and philosopher of science, Science at the Frontiers: Perspectives on the History and Philosophy of Science supplements current literature in the history and philosophy of science with essays approaching the traditional problems of the field from new perspectives and highlighting disciplines usually overlooked by the canon. William H. Krieger brings together scientists from a number of disciplines to answer these questions and more in a volume appropriate for both students and academics in the field.

Background and assumptions. Persistence and philosophy of time ; Atomism and composition ; Scope ; Some matters of methodology -- Persistence, location, and multilocation in spacetime. Endurance, perdurance, exdurance : some pictures ; More pictures ; Temporal modification and the "problem of temporary intrinsics" ; Persistence, location and multilocation in generic spacetime ; An alternative classification -- Classical and relativistic spacetime. Newtonian spacetime ; Neo-Newtonian (Galilean) spacetime ; Reference frames and coordinate systems ; Galilean transformations in spacetime ; Special relativistic (...) spacetime ; Length contraction and time dilation ; Invariant properties of special relativistic spacetime -- Persisting objects in classical spacetime. Enduring, perduring, and exduring objects in Galilean spacetime ; The argument from vagueness ; From minimal D-fusions to temporal parts ; Motivating a sharp cutoff ; Some objections and replies ; Implications -- Persisting objects in Minkowski spacetime. Enduring, perduring, and exduring objects in Minkowski spacetime ; Flat and curved achronal regions in Minkowski spacetime ; Early reflections on persisting objects in Minkowski spacetime : Quine and Smart ; "Profligate ontology"? ; Is achronal universalism tenable in Minkowski spacetime? ; "Crisscrossing" and immanent causation -- Coexistence in spacetime. The notion of coexistence ; Desiderata ; Coexistence in Galilean spacetime ; Coexistence in Minkowski spacetime : CASH ; Alexandrov-Stein present and Alexandrov-Stein coexistence ; AS-Coexistence v. CASH : symmetry, multigrade, and objectivity ; As-coexistence v. CASH : relevance ; The mixed past of coexistence ; No need in the extended now -- Strange coexistence? Coexistence and existence@ ; The asymmetry thesis ; The absurdity thesis ; Collective CASH value of coexistence ; Collective existence@ and coexistence in classical spacetime ; Collective existence@ and coexistence in Minkowski spacetime ; Contextuality ; Chronological incoherence ; Some objections -- Shapes and other arrangements in Minkowski spacetime. How rigid is a granite block? ; Perspectives in space ; Perspectives in spacetime ; Are shapes intrinsic to objects? ; The causal objection ; The micro-reductive objection ; Pegs, boards, and shapes ; Perduring objects exist. (shrink)

Background Studying global health problems requires international multidisciplinary teams. Such multidisciplinarity and multiculturalism create challenges in adhering to a set of ethical principles across different country contexts. Our group on health system responses to violence against women (VAW) included two universities in a European high-income country (HIC) and four universities in low-and middle-income countries (LMICs). This study aimed to investigate professional and policy perspectives on the types, causes of, and solutions to ethical challenges specific to the ethics approval stage of (...) the global research projects on health system responses to VAW. Methods We used the Network of Ethical Relationships model, framework method, and READ approach to analyse qualitative semi-structured interviews (n = 18) and policy documents (n = 27). In March-July 2021, we recruited a purposive sample of researchers and members of Research Ethics Committees (RECs) from the five partner countries. Interviewees signposted policies and guidelines on research ethics, including VAW. Results We developed three themes with eight subthemes summarising ethical challenges across three contextual factors. The global nature of the group contributed towards power and resource imbalance between HIC and LMICs and differing RECs’ rules. Location of the primary studies within health services highlighted differing rules between university RECs and health authorities. There were diverse conceptualisations of VAW and vulnerability of research participants between countries and limited methodological and topic expertise in some LMIC RECs. These factors threatened the timely delivery of studies and had a negative impact on researchers and their relationships with RECs and HIC funders. Most researchers felt frustrated and demotivated by the bureaucratised, uncoordinated, and lengthy approval process. Participants suggested redistributing power and resources between HICs and LMICs, involving LMIC representatives in developing funding agendas, better coordination between RECs and health authorities and capacity strengthening on ethics in VAW research. Conclusions The process of ethics approval for global research on health system responses to VAW should be more coordinated across partners, with equal power distribution between HICs and LMICs, researchers and RECs. While some of these objectives can be achieved through education for RECs and researchers, the power imbalance and differing rules should be addressed at the institutional, national, and international levels. Three of the authors were also research participants, which had potential to introduce bias into the findings. However, rigorous reflexivity practices mitigated against this. This insider perspective was also a strength, as it allowed us to access and contribute to more nuanced understandings to enhance the credibility of the findings. It also helped to mitigate against unequal power dynamics. (shrink)

in D. Dieks (ed.), The Ontology of Spacetime, Vol. 2. Elsevier, forthcoming.

A recent debate has ensued over the claim in Pikovski et al. that systems with internal degrees of freedom undergo a universal, gravity-induced, type of decoherence that explains their quantum-to-classical transition. Such decoherence is supposed to arise from the different gravitational redshifts experienced by such systems when placed in a superposition of two wave packets at different heights in a gravitational field. Here we investigate some aspects of the discussion with the aid of simple examples. In particular, we first resolve (...) an apparent conflict between the reported results and the equivalence principle by noting that the static and free fall descriptions focus on states associated with different hypersurfaces. Next, we emphasize that predictions regarding the observability of interference become relevant only in the context of concrete experimental settings. As a result, we caution against hasty claims of universal validity. Finally, we dispute the claim that, at least in the scenarios discussed in Pikovski et al., gravitation is responsible for the reported results and we question the alleged ability of decoherence to explain the quantum-to-classical transition. In consequence, we argue against the extraordinary assertion in Pikovski et al. that gravity can account for the emergence of classicality. (shrink)

The article discusses the formal classification of natural sciences, which is based on several propositions: (a) natural sciences can be separated onto independent and dependent sciences based on the gnosiologic criterion and irreducibility criteria (principal and technical); (b) there are four independent sciences which form a hierarchy: physics ← chemistry ← terrestrial biology ← human psychology; (c) every independent science except for physics has already developed or will develop in the future a set of final paradigms formulated in the terms (...) of the science one step above it in the hierarchy; (d) some paradigms in physics will never become final; (e) each independent natural science has dependent sciences with paradigms already expressed in the terms of the respective independent sciences. Existing paradigms of independent natural sciences are listed and discussed with respect to the degree of their approach to the final state. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}. (shrink)

The success of deep learning in natural language processing raises intriguing questions about the nature of linguistic meaning and ways in which it can be processed by natural and artificial systems. One such question has to do with subword segmentation algorithms widely employed in language modeling, machine translation, and other tasks since 2016. These algorithms often cut words into semantically opaque pieces, such as ‘period’, ‘on’, ‘t’, and ‘ist’ in ‘period|on|t|ist’. The system then represents the resulting segments in a dense (...) vector space, which is expected to model grammatical relations among them. This representation may in turn be used to map ‘period|on|t|ist’ (English) to ‘par|od|ont|iste’ (French). Thus, instead of being modeled at the lexical level, translation is reformulated more generally as the task of learning the best bilingual mapping between the sequences of subword segments of two languages; and sometimes even between pure character sequences: ‘p|e|r|i|o|d|o|n|t|i|s|t’ → ‘p|a|r|o|d|o|n|t|i|s|t|e’. Such subword segmentations and alignments are at work in highly efficient end-to-end machine translation systems, despite their allegedly opaque nature. The computational value of such processes is unquestionable. But do they have any linguistic or philosophical plausibility? I attempt to cast light on this question by reviewing the relevant details of the subword segmentation algorithms and by relating them to important philosophical and linguistic debates, in the spirit of making artificial intelligence more transparent and explainable. (shrink)

Among the many strengths of Tao Jiang's magnum opus, Origins of Moral-Political Philosophy in Early China, his analysis of the fa tradition (or the fa school, fajia 法家, often misleadingly dubbed Legalists)1 stands out as a major achievement. This achievement is immediately observable from the depth and seriousness with which the fa tradition is covered. Two out of the book's seven chapters (nine if we count Introduction and Conclusion) deal with fa thinkers: chapter 4 is dedicated to Shen Buhai 申不害 (...) (d. 337 b.c.e.), Shang Yang 商鞅 (d. 338 b.c.e.), and Shen Dao 慎到 (fourth century b.c.e.?); chapter 7 deals with Han Fei 韓非 (d. 233 b.c.e.). These chapters account for 112 pages out of the book's 476 (excluding... Read More. (shrink)

In accordance with an old suggestion of Asher Peres (1962), we consider the electromagnetic field as fundamental and the metric as a subsidiary field. In following up this thought, we formulate Maxwell’s theory in a diffeomorphism invariant and metric-independent way. The electromagnetic field is then given in terms of the excitation $H = ({\cal H}, {\cal D})$ and the field strength F = (E,B). Additionally, a local and linear “spacetime relation” is assumed between H and F, namely H ~ κ (...) F, with the constitutive tensor κ. The propagation is studied of electromagnetic wave fronts (surfaces of discontinuity) with a method of Hadamard. We find a generalized Fresnel equation that is quartic in the wave covector of the wave front. We discuss under which conditions the waves propagate along the light cone. Thereby we derive the metric of spacetime, up to a conformal factor, by purely electromagnetic methods. (shrink)

This makes his book especially valuable." -- Yuri Gurevich, Professor of Computer Science, University of Michigan Computability and complexity theory should be of central concern to practitioners as well as theorists.

This chapter explores the relationship between knowing-how and skill, as well other success-in-action notions like dispositions and abilities. I offer a new view of knowledge-how which combines elements of both intellectualism and Ryleanism. According to this view, knowing how to perform an action is both a kind of knowing-that (in accord with intellectualism) and a complex multi-track dispositional state (in accord with Ryle’s view of knowing-how). I argue that this new view—what I call practical attitude intellectualism—offers an attractive set of (...) solutions to various puzzles concerning the connections between knowing-how and abilities and skills to perform intentional actions. (shrink)

How should intellectualists respond to apparent Gettier-style counterexamples? Stanley offers an orthodox response which rejects the claim that the subjects in such scenarios possess knowledge-how. I argue that intellectualists should embrace a revisionary response according to which knowledge-how is a distinctively practical species of knowledge-that that is compatible with Gettier-style luck.

It is often said that ‘what it is like’-knowledge cannot be acquired by consulting testimony or reading books [Lewis 1998; Paul 2014; 2015a]. However, people also routinely consult books like What It Is Like to Go to War [Marlantes 2014], and countless ‘what it is like’ articles and youtube videos, in the apparent hope of gaining knowledge about what it is like to have experiences they have not had themselves. This article examines this puzzle and tries to solve it by (...) appealing to recent work on knowing-wh ascriptions. In closing I indicate the wider significance of these ideas by showing how they can help us to evaluate prominent arguments by Paul [2014; 2015a] concerning transformative experiences. (shrink)

This article examines the method of reflective equilibrium (RE) and its role in philosophical inquiry. It begins with an overview of RE before discussing some of the subtleties involved in its interpretation, including challenges to the standard assumption that RE is a form of coherentism. It then evaluates some of the main objections to RE, in particular, the criticism that this method generates unreasonable beliefs. It concludes by considering how RE relates to recent debates about the role of intuitions in (...) philosophy. (shrink)

In this paper I develop three different arguments against the thesis that knowledge-how is a kind of knowledge-that. Knowledge-that is widely thought to be subject to an anti-luck condition, a justified or warranted belief condition, and a belief condition, respectively. The arguments I give suggest that if either of these standard assumptions is correct then knowledge-how is not a kind of knowledge-that. In closing I identify a possible alternative to the standard Rylean and intellectualist accounts of knowledge-how. This alternative view (...) illustrates that even if the arguments given here succeed it might still be reasonable to hold that knowing how to do something is a matter of standing in an intentional relation to a proposition other than the knowledge-that relation. (shrink)

A common belief is that evolution generally proceeds towards greater complexity at both the organismal and the genomic level, numerous examples of reductive evolution of parasites and symbionts notwithstanding. However, recent evolutionary reconstructions challenge this notion. Two notable examples are the reconstruction of the complex archaeal ancestor and the intron‐rich ancestor of eukaryotes. In both cases, evolution in most of the lineages was apparently dominated by extensive loss of genes and introns, respectively. These and many other cases of reductive evolution (...) are consistent with a general model composed of two distinct evolutionary phases: the short, explosive, innovation phase that leads to an abrupt increase in genome complexity, followed by a much longer reductive phase, which encompasses either a neutral ratchet of genetic material loss or adaptive genome streamlining. Quantitatively, the evolution of genomes appears to be dominated by reduction and simplification, punctuated by episodes of complexification. (shrink)

Is there a successful regress argument against intellectualism? In this article I defend the negative answer. I begin by defending Stanley and Williamson's (2001) critique of the contemplation regress against Noë (2005). I then identify a new argument – the employment regress – that is designed to succeed where the contemplation regress fails, and which I take to be the most basic and plausible form of a regress argument against intellectualism. However, I argue that the employment regress still fails. Drawing (...) on the previous discussion, I criticise further regress arguments given by Hetherington (2006) and Noë (2005). (shrink)

Knowledge-how often appears to be more difficult to transmit by testimony than knowledge-that and knowledge-wh. Some philosophers have argued that this difference provides us with an important objection to intellectualism—the view that knowledge-how is a species of knowledge-that. This article defends intellectualism against these testimony-based objections.

Paul (2014, 2015a) argues that one cannot rationally decide whether to have a transformative experience by trying to form judgments, in advance, about (i) what it would feel like to have that experience, and (ii) the subjective value of having such an experience. The problem is if you haven’t had the experience then you cannot know what it is like, and you need to know what it is like to assess its value. However, in earlier work I argued that ‘what (...) it is like’-knowledge comes in degrees, and I briefly suggested that, consequently, some instances of Paul’s argument schema might commit a fallacy of equivocation. The aim of this paper is to further explore and strengthen this objection by, first, offering a new argument—the modelling argument—in support of it, and then by evaluating a range of replies that might be given to this objection on Paul’s behalf. I conclude that each reply either fails or, at best, only partially succeeds in defending some but not all instances of Paul’s argument schema. In closing, I consider how we might revise Paul’s concepts of transformative experiences and choices in response to this conclusion. (shrink)

What is the relationship between the linguistic properties of knowledge-how ascriptions and the nature of knowledge-how itself? In this chapter I address this question by examining the linguistic methodology of Stanley and Williamson (2011) and Stanley (2011a, 2011b) who defend the intellectualist view that knowledge-how is a kind of knowledge-that. My evaluation of this methodology is mixed. On the one hand, I defend Stanley and Williamson (2011) against critics who argue that the linguistic premises they appeal to—about the syntax and (...) semantics of knowledge-how and knowledge-wh ascriptions—do not establish their desired conclusions about the nature of knowledge-how itself. But, on the other hand, I also criticize the role that linguistic considerations play in Stanley’s (2011a) response to apparent Gettier-style counterexamples to intellectualism. (shrink)

What follows for the ability hypothesis reply to the knowledge argument if knowledge-how is just a form of knowledge-that? The obvious answer is that the ability hypothesis is false. For the ability hypothesis says that, when Mary sees red for the first time, Frank Jackson’s super-scientist gains only knowledge-how and not knowledge-that. In this paper I argue that this obvious answer is wrong: a version of the ability hypothesis might be true even if knowledge-how is a form of knowledge-that. To (...) establish this conclusion I utilize Jason Stanley and Timothy Williamson’s well-known account of knowledge-how as “simply a species of propositional knowledge” . I demonstrate that we can restate the core claims of the ability hypothesis – that Mary only gains new knowledge-how and not knowledge-that – within their account of knowledge-how as a species of knowledge-that. I examine the implications of this result for both critics and proponents of the ability hypothesis. (shrink)

Yuri Balashov sets out major rival views of persistence--endurance, perdurance, and exdurance--in a spacetime framework and proceeds to investigate the implications of Einstein's theory of relativity for the debate about persistence. His overall conclusion--that relativistic considerations favour four-dimensionalism over three-dimensionalism--is hardly surprising. It is, however, anything but trivial. Contrary to a common misconception, there is no straightforward argument from relativity to four-dimensionalism. The issues involved are complex, and the debate is closely entangled with a number of other philosophical disputes, including (...) those about the nature and ontology of time, parts and wholes, material constitution, causation and properties, and vagueness. (shrink)

Scale-free network models describe many natural and social phenomena. In particular, networks of interacting components of a living cell were shown to possess scale-free properties. A recent study(1) compares the system-level properties of metabolic and information networks in 43 archaeal, bacterial and eukaryal species and claims that the scale-free organization of these networks is more conserved during evolution than their content. BioEssays 24:105–109, 2002. Published 2002 Wiley Periodicals, Inc.

The series is devoted to the study of scientific and philosophical texts from the Classical and the Islamic world handed down in Arabic. Through critical text editions and monographs, it provides access to ancient scientific inquiry as it developed in a continuous tradition from Antiquity to the modern period. All editions are accompanied by translations and philological and explanatory notes.

In this paper, the ethical, legal, and social implications of Thailand’s surrogacy regulations from both domestic and global perspectives are explored. Surrogacy tourism in Thailand has expanded since India strengthened its visa regulations in 2012. In 2015, in the wake of a major scandal surrounding the abandonment of a surrogate child by its foreign intended parents, a law prohibiting the practice of surrogacy for commercial purposes was enacted. Consequently, a complete ban on surrogacy tourism was imposed. However, some Thai physicians (...) and surrogate mothers cross into neighboring countries to provide foreign clients with the commercial surrogacy services that are forbidden in Thailand. Under this legislation, the needs of Thai couples who are unable to conceive are accommodated by legally accessible, non-commercial surrogacy services; however, there is currently no provision in place aimed at protecting the rights and interests of surrogate mothers and children. It is widely believed that the abolition of surrogacy tourism, an industry that give rise to several major scandals, and legal access to surrogacy by Thai couples were the Thai government’s primary goal in implementing this legislation. (shrink)

Many philosophers accept a view – what I will call the intuition picture – according to which intuitions are crucial evidence in philosophy. Recently, Williamson has argued that such views are best abandoned because they lead to a psychologistic conception of philosophical evidence that encourages scepticism about the armchair judgements relied upon in philosophy. In this paper I respond to this criticism by showing how the intuition picture can be formulated in such a way that: it is consistent with a (...) wide range of views about not only philosophical evidence but also the nature of evidence in general, including Williamson's famous view that E = K; it can maintain the central claims about the nature and role of intuitions in philosophy made by proponents of the intuition picture; it does not collapse into Williamson's own deflationary view of the nature and role of intuitions in philosophy; and it does not lead to scepticism. (shrink)

This chapter examines some key developments in discussions of the social dimensions of knowing-how, focusing on work on the social function of the concept of knowing-how, testimony, demonstrating one's knowledge to other people, and epistemic injustice. I show how a conception of knowing-how as a form of 'downstream knowledge' can help to unify various phenomena discussed within this literature, and I also consider how these ideas might connect with issues concerning wisdom, moral knowledge, and moral testimony.

Background In an increasingly globalized world, legal protocols related to health care that are both effective and culturally sensitive are paramount in providing excellent quality of care as well as protection for physicians tasked with decision making. Here, we analyze the current medicolegal status of brain death diagnosis with regard to end-of-life care in Japan, China, and South Korea from the perspectives of front-line health care workers. Main body Japan has legally wrestled with the concept of brain death for decades. (...) An inability to declare brain death without consent from family coupled with cultural expectations of family involvement in medical care is mirrored in other Confucian-based cultures and may complicate care for patients from these countries when traveling or working overseas. Within Japan, China, and South Korea, medicolegal shortcomings in the diagnosis of brain death act as a great source of stress for physicians and expose them to potential public and legal scorn. Here, we detail the medicolegal status of brain death diagnosis within Japan and compare it to China and South Korea to find common ground and elucidate the impact of legal ambiguity on health care workers. Conclusion The Confucian cultural foundation of multiple Asian countries raises common issues of family involvement with diagnosis and cultural considerations that must be met. Leveraging public education systems may increase awareness of brain death issues and lead to evolving laws that clarify such end-of-life issues while protecting physicians from sociocultural backlash. (shrink)

Hawley introduced the idea of the client's perspective on knowledge, which she used to illuminate knowing-how and cases of epistemic injustice involving knowing-how. In this paper, I explore how Hawley's idea might be used to illuminate not only knowing-how, but other forms of knowledge that, like knowing-how, are often claimed to be distinct from mere knowing-that, focusing on the case studies of moral understanding and ‘what it is like’-knowledge.